Phenotypes associated with this allele

• Allele Symbol: Hgd^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6416342
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hgd^tm1c(KOMP)Wtsi/Hgd^tm1c(KOMP)Wtsi Tg(Mx1-cre)1Cgn/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6416347

Genotype
MGI:6416347

cn1

• Allelic Composition: Hgd^{tm1c(KOMP)Wtsi}/Hgd^{tm1c(KOMP)Wtsi}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:287389 )

• mice injected with pIpC show increased plasma homogentisic acid (HGA) levels

abnormal urine homeostasis ( J:287389 )

• mice show a relatively small increase in urinary HGA following pIpC injection

renal/urinary system

abnormal urine homeostasis ( J:287389 )

• mice show a relatively small increase in urinary HGA following pIpC injection

skeleton

abnormal articular cartilage morphology ( J:287389 )

• few or no pigmented chondrons are seen in the calcified articular cartilage of knee joints at 9 weeks post pIpC injection, but increased numbers are seen at 15 and 20 weeks post pIpC