Phenotypes associated with this allele

• Allele Symbol: Rere^tm1Dsco
• Allele Name: targeted mutation 1, Daryl Scott
• Allele ID: MGI:6416530
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rere^tm1Dsco/Rere^tm1Dsco H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:7343556

Genotype
MGI:7343556

cn1

• Allelic Composition: Rere^tm1Dsco/Rere^tm1Dsco; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:306308 )

• mice are reported to exhibit perinatal lethality with no pups recovered at P0

• however, fetuses are found at Mendelian ratios at E15.5

craniofacial

abnormal palatal mesenchymal cell proliferation ( J:306308 )

• at E13.5, proliferation of mesenchymal cells is significantly reduced in the medial (oral) halves of the palatal shelves

• however, proliferative activity in the lateral halves of the palatal shelves is normal at E13.5

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, bilateral palatal shelves are elevated into horizontal position but fail to meet in the midline

decreased palatal shelf size ( J:306308 )

• at E13.5, the size of palatal shelves is smaller than that of control embryos in the anterior region

cleft palate ( J:306308 )

• at E15.5, cleft palate is observed along the anterior-posterior axis

delayed palatal shelf elevation ( J:306308 )

• at E14.5, palatal shelves remain in vertical position and are not horizontally elevated, unlike in controls

• however, vertical outgrowth of the palatal shelves is normal at E13.5

digestive/alimentary system

abnormal palatal mesenchymal cell proliferation ( J:306308 )

• at E13.5, proliferation of mesenchymal cells is significantly reduced in the medial (oral) halves of the palatal shelves

• however, proliferative activity in the lateral halves of the palatal shelves is normal at E13.5

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, bilateral palatal shelves are elevated into horizontal position but fail to meet in the midline

decreased palatal shelf size ( J:306308 )

• at E13.5, the size of palatal shelves is smaller than that of control embryos in the anterior region

cleft palate ( J:306308 )

• at E15.5, cleft palate is observed along the anterior-posterior axis

delayed palatal shelf elevation ( J:306308 )

• at E14.5, palatal shelves remain in vertical position and are not horizontally elevated, unlike in controls

• however, vertical outgrowth of the palatal shelves is normal at E13.5

growth/size/body

abnormal palatal mesenchymal cell proliferation ( J:306308 )

• at E13.5, proliferation of mesenchymal cells is significantly reduced in the medial (oral) halves of the palatal shelves

• however, proliferative activity in the lateral halves of the palatal shelves is normal at E13.5

palatal shelves fail to meet at midline ( J:306308 )

• at E15.5, bilateral palatal shelves are elevated into horizontal position but fail to meet in the midline

decreased palatal shelf size ( J:306308 )

• at E13.5, the size of palatal shelves is smaller than that of control embryos in the anterior region

cleft palate ( J:306308 )

• at E15.5, cleft palate is observed along the anterior-posterior axis

delayed palatal shelf elevation ( J:306308 )

• at E14.5, palatal shelves remain in vertical position and are not horizontally elevated, unlike in controls

• however, vertical outgrowth of the palatal shelves is normal at E13.5