Phenotypes associated with this allele

• Allele Symbol: Gpr27^tm1Tac
• Allele Name: targeted mutation 1, Taconic
• Allele ID: MGI:6423080
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr27^tm1Tac/Gpr27^tm1Tac	B6.129S-Gpr27^tm1Tac	MGI:6456975

Genotype
MGI:6456975

hm1

• Allelic Composition: Gpr27^tm1Tac/Gpr27^tm1Tac
• Genetic Background: B6.129S-Gpr27^tm1Tac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:286854 )

• at 12 weeks of age, chow-fed mice are 10% lighter than wild-type controls

• however, no significant difference in body weight is observed after high-fat feeding

homeostasis/metabolism

decreased insulin secretion ( J:286854 )

• at 12 weeks of age, chow-fed mice show a significant reduction in plasma insulin measured 15 minutes after glucose challenge

• however, isolated islets show no defect in fractional insulin secretion in response to glucose or potassium chloride stimulation

decreased circulating insulin level ( J:286854 )

• on a chow diet, plasma insulin levels are reduced but insulin sensitivity is normal

• plasma insulin levels are also decreased after high-fat feeding

impaired glucose tolerance ( J:286854 )

• on a chow diet, mice show slightly impaired glucose tolerance at 12 weeks of age

• mildly impaired glucose tolerance is also observed after high-fat feeding

endocrine/exocrine glands

abnormal endocrine pancreas physiology ( J:286854 )

• Ins1/2 and Pdx1 mRNA are reduced by 30% in pancreatic islets

• however, no reduction in islet insulin content or beta cell mass is observed and the distribution of islet sizes is normal

decreased insulin secretion ( J:286854 )

• at 12 weeks of age, chow-fed mice show a significant reduction in plasma insulin measured 15 minutes after glucose challenge

• however, isolated islets show no defect in fractional insulin secretion in response to glucose or potassium chloride stimulation