Analysis Tools
mortality/aging
|
• all mice die within 8 hours of birth
|
integument
|
• 14.8 times higher trans-epidermal water loss in newborn mice compared with heterozygotes
|
|
• slightly more layers than in control mice
|
|
• thicker than in control cells
|
|
• impaired (thin) lipid lamella formation with small, immature, granular lamellar bodies
|
reddish skin
(
J:286705
)
|
• at E18.5
|
shiny skin
(
J:286705
)
|
• at E18.5
|
|
• at E18.5
|
growth/size/body
weight loss
(
J:286705
)
|
• rapid weight loss after birth due to trans-epidermal water loss
|
homeostasis/metabolism
|
• 14.8 times higher trans-epidermal water loss in newborn mice compared with heterozygotes
|
|
• almost complete loss of acylceramide and its precursor omega-hydroxy ceramide in the epidermis of E18.5 mice
• however, other lipid levels are normal
|
embryo
|
• persistent on the outer most layer of epidermis
|
