Phenotypes associated with this allele

• Allele Symbol: Slxl1^em1.1Jbmu
• Allele Name: endonuclease-mediated mutation 1.1, Jacob Mueller
• Allele ID: MGI:6423420
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Slx^em1.1JbmuSlxl1^em1.1Jbmu/Y	involves: C57BL/6NHsd * DBA/2NHsd * FVB/N	MGI:6729183
ot2	Slxl1^em1.1Jbmu/Y	involves: C57BL/6NHsd * DBA/2NHsd * FVB/N	MGI:6729184

Genotype
MGI:6729183

cx1

• Allelic Composition: Slx^em1.1JbmuSlxl1^em1.1Jbmu/Y
• Genetic Background: involves: C57BL/6NHsd * DBA/2NHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:304511 )

♂ • at stage 7/8 with delay in transition from round spermatids to elongated spermatids

♂ • however, meiosis is normal as round spermatid successfully fertilize oocytes

oligozoospermia ( J:304511 )

♂ • severe

teratozoospermia ( J:304511 )

♂ • failure to transition from round spermatids to elongated spermatids

globozoospermia ( J:304511 )

♂

male infertility ( J:304511 )

♂

cellular

oligozoospermia ( J:304511 )

♂ • severe

teratozoospermia ( J:304511 )

♂ • failure to transition from round spermatids to elongated spermatids

globozoospermia ( J:304511 )

♂

Genotype
MGI:6729184

ot2

• Allelic Composition: Slxl1^em1.1Jbmu/Y
• Genetic Background: involves: C57BL/6NHsd * DBA/2NHsd * FVB/N

reproductive system

reproductive system phenotype ( J:304511 )

♂N • mice exhibit wild-type fertility, fecundity, testis weights, sperm counts, and no observable spermatogenic defects

transmission ratio distortion ( J:304511 )

♂ • more male pups than expected are produced