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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdcd7em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6423840
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdcd7em1(IMPC)Mbp/Pdcd7em1(IMPC)Mbp C57BL/6NCrl-Pdcd7em1(IMPC)Mbp/Mmucd MGI:6696847
ht2
 		Pdcd7em1(IMPC)Mbp/Pdcd7+ C57BL/6NCrl-Pdcd7em1(IMPC)Mbp/Mmucd MGI:6696846


Genotype
MGI:6696847
hm1
Allelic
Composition		 Pdcd7em1(IMPC)Mbp/Pdcd7em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Pdcd7em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd7em1(IMPC)Mbp mutation (1 available); any Pdcd7 mutation (14 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Pdcd7em1(IMPC)Mbp/Pdcd7em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form irregular outgrowths with no apparent inner cell mass colony or trophoblast giant cells.

embryo
absent inner cell mass ( J:279207 )
• in vitro outgrowth assays show no apparent inner cell mass (ICM) colony after 3 days in culture
absent trophoblast giant cells ( J:279207 )
• in vitro, no trophoblast giant cells (TGCs) are apparent after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• although early blastocysts are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:6696846
ht2
Allelic
Composition		 Pdcd7em1(IMPC)Mbp/Pdcd7+
Genetic
Background		 C57BL/6NCrl-Pdcd7em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd7em1(IMPC)Mbp mutation (1 available); any Pdcd7 mutation (14 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

embryo

endocrine/exocrine glands
enlarged testis ( J:211773 )
IMPC - UCD

hematopoietic system

homeostasis/metabolism

liver/biliary system
small liver ( J:211773 )
IMPC - UCD

reproductive system
enlarged testis ( J:211773 )
IMPC - UCD

vision/eye
cataract ( J:211773 )
IMPC - UCD
microphthalmia ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory