Phenotypes associated with this allele

• Allele Symbol: BC028528^tm1.1Smoc
• Allele Name: targeted mutation 1.1, Shanghai Model Organisms Center
• Allele ID: MGI:6429948
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	BC028528^tm1.1Smoc/BC028528^tm1.1Smoc	B6.Cg-BC028528^tm1.1Smoc	MGI:6429950

Genotype
MGI:6429950

hm1

• Allelic Composition: BC028528^tm1.1Smoc/BC028528^tm1.1Smoc
• Genetic Background: B6.Cg-BC028528^tm1.1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:287433 )

• survival rate of mutants following kidney IRI is lower (60% vs 90% in wild-type mice)

increased susceptibility to injury ( J:287433 )

• mice exhibit impaired and delayed post-ischemia-reperfusion injury (IRI) renal recovery, showing higher levels of serum blood urea and creatinine, lower survival rate, no clearance of PAS+ intraluminal debris or brush-border recovery at the corticomedullary junction, greater renal fibrosis. and fewer proliferating tubular epithelial cells 3 days after IRI

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:287433 )

• survival rate of mutants following kidney IRI is lower (60% vs 90% in wild-type mice)

renal/urinary system

renal/urinary system phenotype ( J:287433 )

N • mice show normal serum blood urea nitrogen and creatinine levels at baseline