Phenotypes associated with this allele

• Allele Symbol: Cxcr4^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6430655
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr4^em1(IMPC)Mbp/Cxcr4^em1(IMPC)Mbp	C57BL/6NCrl-Cxcr4^em1(IMPC)Mbp/MbpMmucd	MGI:7414852
ht2	Cxcr4^em1(IMPC)Mbp/Cxcr4^+	C57BL/6NCrl-Cxcr4^em1(IMPC)Mbp/MbpMmucd	MGI:7414851

Genotype
MGI:7414852

hm1

• Allelic Composition: Cxcr4^em1(IMPC)Mbp/Cxcr4^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Cxcr4^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Cxcr4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta size ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

limbs/digits/tail

abnormal limb morphology ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:7414851

ht2

• Allelic Composition: Cxcr4^em1(IMPC)Mbp/Cxcr4⁺
• Genetic Background: C57BL/6NCrl-Cxcr4^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Cxcr4

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta size ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

hematopoietic system

increased leukocyte cell number ( J:211773 )

♂

IMPC - UCD

increased lymphocyte cell number ( J:211773 )

♂

IMPC - UCD

increased monocyte cell number ( J:211773 )

IMPC - UCD

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♀

IMPC - UCD

immune system

increased leukocyte cell number ( J:211773 )

♂

IMPC - UCD

increased lymphocyte cell number ( J:211773 )

♂

IMPC - UCD

increased monocyte cell number ( J:211773 )

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

vision/eye

cataract ( J:211773 )

♂

IMPC - UCD

microphthalmia ( J:211773 )

IMPC - UCD

abnormal eyelid morphology ( J:211773 )

♀

IMPC - UCD

abnormal vitreous body morphology ( J:211773 )

♂

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD