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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup93em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6430664
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nup93em1(IMPC)Mbp/Nup93em1(IMPC)Mbp C57BL/6NCrl-Nup93em1(IMPC)Mbp/Mmucd MGI:7388748
ht2
 		Nup93em1(IMPC)Mbp/Nup93+ C57BL/6NCrl-Nup93em1(IMPC)Mbp/Mmucd MGI:7768395


Genotype
MGI:7388748
hm1
Allelic
Composition		 Nup93em1(IMPC)Mbp/Nup93em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Nup93em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup93em1(IMPC)Mbp mutation (1 available); any Nup93 mutation (48 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Nup93em1(IMPC)Mbp/Nup93em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocytsts in vitro hatch from the zona and form irregular outgrowths with no apparent inner cell mass or trophoblast giant cells.

embryo
absent inner cell mass ( J:279207 )
• in vitro outgrowth assays show no apparent inner cell mass (ICM) colony after 3 days in culture
absent trophoblast giant cells ( J:279207 )
• in vitro, no trophoblast giant cells (TGCs) are apparent after 3 days in culture

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• although early blastocysts are present in approximate Mendelian ratios at E3.5 (30% versus expected 25%, n=20), no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7768395
ht2
Allelic
Composition		 Nup93em1(IMPC)Mbp/Nup93+
Genetic
Background		 C57BL/6NCrl-Nup93em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup93em1(IMPC)Mbp mutation (1 available); any Nup93 mutation (48 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory