Phenotypes associated with this allele

• Allele Symbol: Rcbtb2^tm1.1Xyw
• Allele Name: targeted mutation 1.1, Xiao-Yan Wen
• Allele ID: MGI:6431098
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcbtb2^tm1.1Xyw/Rcbtb2^tm1.1Xyw	involves: C57BL/6 * CBA	MGI:6431136
ht2	Rcbtb2^tm1.1Xyw/Rcbtb2^+	involves: C57BL/6 * CBA	MGI:6431137

Genotype
MGI:6431136

hm1

• Allelic Composition: Rcbtb2^tm1.1Xyw/Rcbtb2^tm1.1Xyw
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:282928 )

• tumors are most commonly seen in the spleen, mesenteric lymph nodes, liver, and intestines

• tumors are present in 20 of 25 mice at 18-26 months of age compared to 5 of 19 wild-type controls

increased gastrointestinal tumor incidence ( J:282928 )

• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface

increased liver tumor incidence ( J:282928 )

increased lymphoma incidence ( J:282928 )

• some mice have histiocyte-associated lymphoma or B cell lymphoma co-occurring with histiocytic sarcoma

increased histiocytic sarcoma incidence ( J:282928 )

• tumor cell morphology is frequently consistent with malignant histiocytes, although in some mice tumors have a plasma cell appearance

hematopoietic system

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

abnormal bone marrow cell physiology ( J:282928 )

• cells from 8-12 week old mice display enhanced viability in response to LPS in culture

abnormal splenocyte physiology ( J:282928 )

• splenocytes from 8-12 week old mice display enhanced viability in response to LPS in culture

immune system

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

abnormal splenocyte physiology ( J:282928 )

• splenocytes from 8-12 week old mice display enhanced viability in response to LPS in culture

enlarged mesenteric lymph nodes ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

liver/biliary system

increased liver tumor incidence ( J:282928 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:282928 )

• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface

growth/size/body

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant histiocytic disease		DOID:2570		J:282928

Genotype
MGI:6431137

ht2

• Allelic Composition: Rcbtb2^tm1.1Xyw/Rcbtb2⁺
• Genetic Background: involves: C57BL/6 * CBA

neoplasm

increased tumor incidence ( J:282928 )

• tumors are present in 10 of 18 mice at 18-26 months of age compared to 5 of 19 wild-type controls

• tumors are most commonly seen in the spleen, mesenteric lymph nodes, liver, and intestines

• mice typically have multiple tumor bearing organs

increased gastrointestinal tumor incidence ( J:282928 )

• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface

increased liver tumor incidence ( J:282928 )

increased lymphoma incidence ( J:282928 )

• some mice have histiocyte-associated lymphoma or B cell lymphoma co-occurring with histiocytic sarcoma

increased histiocytic sarcoma incidence ( J:282928 )

• tumor cell morphology is frequently consistent with malignant histiocytes, although in some mice tumors have a plasma cell appearance

hematopoietic system

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

immune system

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

enlarged mesenteric lymph nodes ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

liver/biliary system

increased liver tumor incidence ( J:282928 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:282928 )

• tumors in the lower gastrointestinal tract often lead to destruction of the mucosal surface

growth/size/body

enlarged spleen ( J:282928 )

• frequently enlarged due to proliferation of transformed cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant histiocytic disease		DOID:2570		J:282928