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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfap69em1Fzh
endonuclease-mediated mutation 1, Feng Zhang
MGI:6431857
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cfap69em1Fzh/Cfap69em1Fzh involves: C57BL/6J MGI:6431858


Genotype
MGI:6431858
hm1
Allelic
Composition		 Cfap69em1Fzh/Cfap69em1Fzh
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfap69em1Fzh mutation (0 available); any Cfap69 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm flagellum morphology ( J:288345 )
• no normal sperm flagella are seen; sperm show absent flagella, short, coiled, bent and irregular-caliber flagella
• however, no differences in seminiferous tubule structure or spermatogenic cells are seen
abnormal outer dense fiber morphology ( J:288345 )
• outer dense fibers are chaotically scattered
abnormal sperm axoneme morphology ( J:288345 )
• microtubule doublets are chaotically scattered
short sperm flagellum ( J:288345 )
• testicular and epididymal spermatozoa exhibit short flagella
abnormal sperm head morphology ( J:288345 )
• 89.5% of sperm heads are abnormal, with abnormal head shape and acrosome

cellular
abnormal sperm flagellum morphology ( J:288345 )
• no normal sperm flagella are seen; sperm show absent flagella, short, coiled, bent and irregular-caliber flagella
• however, no differences in seminiferous tubule structure or spermatogenic cells are seen
abnormal outer dense fiber morphology ( J:288345 )
• outer dense fibers are chaotically scattered
abnormal sperm axoneme morphology ( J:288345 )
• microtubule doublets are chaotically scattered
short sperm flagellum ( J:288345 )
• testicular and epididymal spermatozoa exhibit short flagella
abnormal sperm head morphology ( J:288345 )
• 89.5% of sperm heads are abnormal, with abnormal head shape and acrosome

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
spermatogenic failure 24 DOID:0111929 OMIM:617959
 J:288345




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory