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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr35em1Niess
endonuclease-mediated mutation 1, Jan Hendrik Niess
MGI:6436880
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr35em1Niess/Gpr35em1Niess C57BL/6N-Gpr35em1Niess MGI:6502845


Genotype
MGI:6502845
hm1
Allelic
Composition		 Gpr35em1Niess/Gpr35em1Niess
Genetic
Background		 C57BL/6N-Gpr35em1Niess
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr35em1Niess mutation (0 available); any Gpr35 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased colon length ( J:300275 )
• in DSS-treated mice
increased susceptibility to induced colitis ( J:300275 )
• DSS-treated mice exhibit elevated body weight loss, increased disease activity scores, shorter colons, and higher histological colitis scores compared with wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:300275 )
• in DSS-treated mice

immune system
immune system phenotype ( J:300275 )
N
• mice exhibit normal colonic myeloid compartment
increased susceptibility to induced colitis ( J:300275 )
• DSS-treated mice exhibit elevated body weight loss, increased disease activity scores, shorter colons, and higher histological colitis scores compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory