Phenotypes associated with this allele

• Allele Symbol: Exosc7^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6437048
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exosc7^em1(IMPC)Bay/Exosc7^em1(IMPC)Bay	C57BL/6N-Exosc7^em1(IMPC)Bay/BayMmucd	MGI:7471992
hm2	Exosc7^em1(IMPC)Bay/Exosc7^em1(IMPC)Bay	C57BL/6NJ-Exosc7^em1(IMPC)Bay/Mmmh	MGI:7720155

Genotype
MGI:7471992

hm1

• Allelic Composition: Exosc7^em1(IMPC)Bay/Exosc7^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Exosc7^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Exosc7

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:7720155

hm2

• Allelic Composition: Exosc7^em1(IMPC)Bay/Exosc7^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Exosc7^em1(IMPC)Bay/Mmmh

Exosc7^em1(IMPC)Bay/Exosc7^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form irregular outgrowths.

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocyst-like embryos are present at E3.5 (15% versus expected 25%, n=33); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture