All Phenotypes Spaca6<em2Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spaca6^em2Osb
endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
MGI:6437562

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spaca6^em2Osb/Spaca6^em2Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6437564

Allelic Composition	Spaca6^em2Osb/Spaca6^em2Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spaca6^em2Osb mutation (3 available); any Spaca6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:289149 )

• spermatozoa are unable to fertilize cumulus-intact oocytes and accumulate in the perivitelline space during in vitro fertilization

• spermatozoa are unable to fertilize zona pellucida-free oocytes

• however, testis appearance, size and weight are normal, testis epididymides show normal histology, and sperm exhibit normal morphology and motility

failure of sperm-egg fusion ( J:289149 )

• spermatozoa are able to bind to the oocyte surface but rarely fuse with the oocyte membrane

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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