About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shank3tm2Cmpl
targeted mutation 2, Craig M Powell
MGI:6437927
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Shank3tm2Cmpl/Shank3tm2Cmpl B6.129S6-Shank3tm2Cmpl MGI:6437930
ht2
Shank3tm2Cmpl/Shank3+ B6.129S6-Shank3tm2Cmpl MGI:6437929


Genotype
MGI:6437930
hm1
Allelic
Composition
Shank3tm2Cmpl/Shank3tm2Cmpl
Genetic
Background
B6.129S6-Shank3tm2Cmpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm2Cmpl mutation (0 available); any Shank3 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased latency to reach the hidden platform in the Morris water maze
• mice show an increase in distance traveled before reaching the hidden platform during training on the Morris water maze
• mice spend more time in the periphery or thigmotaxis zone of the Morris water maze
• mice show no preference for the target quadrant during the probe test for spatial memory 24 hours following the final training session
• mice show a decrease in the number of marbles buried in the marble-burying task
• however, mice spend similar time in the central, anxiogenic region of the open field as wild-type mice, show a similar latency to enter the light chamber in the dark/light test, and spend similar time in the light and dark chambers, indicating normal anxiety-related responses in these tests, and exhibit normal acoustic startle response and prepulse inhibition
• mice show increased time spend grooming
• females show a decreased latency to fall from the rotarod
• females show less rearing while males only show a trend toward less rearing
• mice show a decrease in approach of a novel, caged social target in the caged conspecific test
• in the genotype and sex-matched social interaction test, mice show a reduction in social interaction time and a decrease in number of social bouts
• in the third trial of the 3-chamber test of sociability, mice do not show a preference for the social novelty
• mice show deficits in social recognition in the social interaction with juvenile test of social memory

nervous system
• mice exhibit impaired hippocampal long-term plasticity
• however, mice show no differences from wild-type mice in basal synaptic transmission and short-term plasticity at hippocampal synapses
• mice exhibit altered striatal glutamatergic synaptic transmission as indicated by a decreased NMDAR/AMPAR ratio in dorsal striatum
• mice exhibit decreased hippocampal long-term potentiation
• however, mGluR-dependent long-term depression is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:289874




Genotype
MGI:6437929
ht2
Allelic
Composition
Shank3tm2Cmpl/Shank3+
Genetic
Background
B6.129S6-Shank3tm2Cmpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm2Cmpl mutation (0 available); any Shank3 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• while mice decreased initial coordination on day one of the rotarod, they show improved motor learning retention of day 2 of testing
• mice show a decrease in the number of marbles buried in the marble-burying task
• however, mice spend similar time in the central, anxiogenic region of the open field as wild-type mice, show similar latency to enter the light chamber in the dark/light test, and spend similar time in the light and dark chambers, and exhibit normal acoustic startle response and prepulse inhibition
• mice show increased time spend grooming
• females show decreased latency to fall from the rotarod on day one, however mice show improved motor learning retention on day 2 of testing
• females show less rearing while males only show a trend toward less rearing
• in the second trial of the 3-chamber test of sociability, mice do not show a preference for the social target over the inanimate object
• in the third trial of the 3-chamber test of sociability, mice do not show a preference for the social novelty
• mice show deficits in social recognition in the social interaction with juvenile test of social memory

nervous system
• mice exhibit decreased hippocampal long-term potentiation
• however, mGluR-dependent long-term depression is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:289874





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory