Analysis Tools
behavior/neurological
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• mice exhibit normal locomotor activity and locomotor habituation, normal ambulatory movement and fine movement, and unchanged motor coordination and learning on the accelerating rotarod
• mice show no differences in anxiety-related behavior in the open field, dark/light, and elevated plus maze tasks, show normal marble burying and nest building and show normal acoustic startle reflex and prepulse inhibition
• mice show no differences in both cued and contextual fear conditioning
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• in the novel object recognition test, mice show no preference for novel object B over control object C compared to wild-type mice which show a preference for the new object B
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• during a spatial test, mice show no preference for object A in the new location compared to wild-type mice which show a preference for object A
• however, mice show normal long-term spatial memory in the Morris water maze
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• mice show an increase in % thigmotaxis across training days in the Morris water maze
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• mice spend almost twice as much time grooming in a novel home-cage than wild-type mice; this is due increased time grooming per bout and not due to increased number of grooming bouts
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• mice interact less times and spend less time physically interacting with their sex and genotype-matched counterpart in the open field than wild-type mice
• however, mice show normal social recognition in the social interaction with juvenile test of social memory, and normal social interaction with a caged adult
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• pups temporarily isolated from their mothers emit more ultrasonic vocalization calls than wild-type mice at P4 and P6
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nervous system
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• mice exhibit altered hippocampal synaptic plasticity
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• NMDA/AMPA ratio is decreased at glutamatergic synapses onto medium spiny neurons indicating that striatal excitatory transmission is impaired
• however, no difference in mEPSC amplitude or frequency is seen in the striatum and mice do not show altered synaptic transmission at hippocampal synapses
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• mice show decreased hippocampal long-term potentiation
• however, mGluR-dependent long-term depression is not altered
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:289884 | ||
| Phelan-McDermid syndrome | DOID:0080354 |
OMIM:606232 |
J:289884 | |
