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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmdem4Eno
endonuclease-mediated mutation 4, Eric N Olson
MGI:6438148
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dmdem4Eno/Dmdem4Eno C57BL/6-Dmdem4Eno MGI:6438177
ot2
 		Dmdem4Eno/Y C57BL/6-Dmdem4Eno MGI:6438180


Genotype
MGI:6438177
hm1
Allelic
Composition		 Dmdem4Eno/Dmdem4Eno
Genetic
Background		 C57BL/6-Dmdem4Eno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdem4Eno mutation (0 available); any Dmd mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
myositis ( J:285447 )
• 4-week old mice exhibit inflammatory infiltration in muscles
centrally nucleated skeletal muscle fibers ( J:285447 )
• muscles show regenerative fibers with centralized nuclei
skeletal muscle fibrosis ( J:285447 )
• in 4-week old mice
dystrophic muscle ( J:285447 )
• mice exhibit severe muscular dystrophy phenotype as indicated by fibrosis, inflammatory infiltration, and regenerative fibers with centralized nuclei at 4 weeks of age
muscle weakness ( J:285447 )
• mice exhibit an approximate 50% decrease in the specific and absolute tetanic force in the extensor digitorum longus muscle at 4 weeks of age

behavior/neurological
decreased grip strength ( J:285447 )
• grip strength analysis indicates a decrease in muscle strength in 8 week old mice

homeostasis/metabolism
increased circulating creatine kinase level ( J:285447 )
• serum creatine kinase levels are elevated 22-fold

immune system
myositis ( J:285447 )
• 4-week old mice exhibit inflammatory infiltration in muscles

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
 J:285447




Genotype
MGI:6438180
ot2
Allelic
Composition		 Dmdem4Eno/Y
Genetic
Background		 C57BL/6-Dmdem4Eno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdem4Eno mutation (0 available); any Dmd mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
myositis ( J:285447 )
• 4-week old mice exhibit inflammatory infiltration in muscles
centrally nucleated skeletal muscle fibers ( J:285447 )
• muscles show regenerative fibers with centralized nuclei
skeletal muscle fibrosis ( J:285447 )
• in 4-week old mice
dystrophic muscle ( J:285447 )
• mice exhibit severe muscular dystrophy phenotype as indicated by fibrosis, inflammatory infiltration, and regenerative fibers with centralized nuclei at 4 weeks of age
muscle weakness ( J:285447 )
• mice exhibit an approximate 50% decrease in the specific and absolute tetanic force in the extensor digitorum longus muscle at 4 weeks of age

behavior/neurological
decreased grip strength ( J:285447 )
• grip strength analysis indicates a decrease in muscle strength in 8 week old mice

homeostasis/metabolism
increased circulating creatine kinase level ( J:285447 )
• serum creatine kinase levels are elevated 22-fold

immune system
myositis ( J:285447 )
• 4-week old mice exhibit inflammatory infiltration in muscles

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
 J:285447




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory