All Phenotypes Pex16<tm1c(EUCOMM)Hmgu> MGI Mouse

increased susceptibility to induced morbidity/mortality ( J:270463 )

• in cold exposed mice

homeostasis/metabolism phenotype ( J:270463 )

N	• mice fed a high-fat diet exhibit normal resting energy metabolism

increased susceptibility to diet-induced obesity ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• cold exposed mice exhibit whitening of brown adipose tissue and increased lethality unlike control mice

• however, diet-induced obesity is normal at 30 degrees Celcius

impaired adaptive thermogenesis ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• however, diet-induced obesity is normal at 30 degrees Celcius and thermogenesis is recused by a diet containing alkylglycerols

decreased oxygen consumption ( J:270463 )

• reduced oxygen consumption after treatment with norepinephrine

impaired glucose tolerance ( J:270463 )

• in mice fed standard chow

• however, no difference is observed when mice are fed a high-fat diet

abnormal response/metabolism to endogenous compounds ( J:270463 )

• reduced oxygen consumption after treatment with norepinephrine

increased total body fat amount ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

increased brown fat cell lipid droplet size ( J:270463 )

• in cold exposed mice

whitened brown adipose tissue morphology ( J:270463 )

• after cold treatment, brown adipose tissue is paler with higher levels of triglyceride content compared with control mice

• however, mitochondria cristae are normal

decreased fat cell mitochondrial DNA content ( J:270463 )

• in brown adipose tissue at 22 and 4 degrees Celsius

• in white adipose tissue at 4 degrees Celsius

• however, mitochondrial DNA content is recused by a diet containing alkylglycerols

increased white fat cell size ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

increased gonadal fat pad weight ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

increased susceptibility to diet-induced obesity ( J:270463 )

• in mice fed a high-fat diet at 22 degrees Celcius

• cold exposed mice exhibit whitening of brown adipose tissue and increased lethality unlike control mice

• however, diet-induced obesity is normal at 30 degrees Celcius

behavior/neurological phenotype ( J:270463 )

N	• mice fed a high-fat diet exhibit normal food intake and physical activity

decreased fat cell mitochondrial DNA content ( J:270463 )

• in brown adipose tissue at 22 and 4 degrees Celsius

• in white adipose tissue at 4 degrees Celsius

• however, mitochondrial DNA content is recused by a diet containing alkylglycerols

abnormal mitochondrial physiology ( J:270463 )

• impaired mitochondrial fatty acid oxidation and modest reduction in citrate synthase activity

• however, mitochondrial function is improved by a diet containing alkylglycerols

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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