Phenotypes associated with this allele

• Allele Symbol: Card14^em1Tshu
• Allele Name: endonuclease-mediated mutation 1, Tsinghua University
• Allele ID: MGI:6441135
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card14^em1Tshu/Card14^em1Tshu	C57BL/6-Card14^em1Tshu	MGI:6441191

Genotype
MGI:6441191

hm1

• Allelic Composition: Card14^em1Tshu/Card14^em1Tshu
• Genetic Background: C57BL/6-Card14^em1Tshu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to chemically induced skin inflammation ( J:289239 )

• mice show decreased susceptibility to imiquimod-induced psoriasis-like skin inflammation, showing less swelling, epidermal acanthosis, skin inflammation, and proliferation of keratinocytes in the back skin and ears than wild-type mice

• mice show reduced infiltration of CD45+, Ly6G+, CD11c+, and F4/80+ cells in the ears and back skin, decreased proportion of infiltrated CCR6+ T cells and decreased percentage of IL-17A-producting cells in the epidermis and dermis of following imiquimod-induced psoriasis-like skin inflammation

integument

decreased susceptibility to chemically induced skin inflammation ( J:289239 )

• mice show decreased susceptibility to imiquimod-induced psoriasis-like skin inflammation, showing less swelling, epidermal acanthosis, skin inflammation, and proliferation of keratinocytes in the back skin and ears than wild-type mice

• mice show reduced infiltration of CD45+, Ly6G+, CD11c+, and F4/80+ cells in the ears and back skin, decreased proportion of infiltrated CCR6+ T cells and decreased percentage of IL-17A-producting cells in the epidermis and dermis of following imiquimod-induced psoriasis-like skin inflammation