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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rabl3xm
xiamen
MGI:6441472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rabl3xm/Rabl3xm C57BL/6J-Rabl3xm MGI:6441540
ht2
 		Rabl3xm/Rabl3em1Btlr C57BL/6J-Rabl3xm Rabl3em1Btlr MGI:6441542


Genotype
MGI:6441540
hm1
Allelic
Composition		 Rabl3xm/Rabl3xm
Genetic
Background		 C57BL/6J-Rabl3xm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabl3xm mutation (0 available); any Rabl3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell morphology ( J:287198 )
• increased CD44 expression in CD8+ T cells
abnormal T cell number ( J:287198 )
• increased CD4+ to CD8+ T cell ratio
• reduced CD3+ T cell frequencies
• increased B cell to T cell ratio

immune system
abnormal T cell morphology ( J:287198 )
• increased CD44 expression in CD8+ T cells
abnormal T cell number ( J:287198 )
• increased CD4+ to CD8+ T cell ratio
• reduced CD3+ T cell frequencies
• increased B cell to T cell ratio




Genotype
MGI:6441542
ht2
Allelic
Composition		 Rabl3xm/Rabl3em1Btlr
Genetic
Background		 C57BL/6J-Rabl3xm Rabl3em1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabl3em1Btlr mutation (0 available); any Rabl3 mutation (18 available)
Rabl3xm mutation (0 available); any Rabl3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

growth/size/body
decreased birth body size ( J:287198 )
• 30% smaller than WT littermates

hematopoietic system
hematopoietic system phenotype ( J:287198 )
N
• normal numbers of monocytes, platelets and neutrophils

immune system

mortality/aging
prenatal lethality, incomplete penetrance ( J:287198 )
• slightly lower than expected Mendelian ratio




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory