About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rabl3xm
xiamen
MGI:6441472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rabl3xm/Rabl3xm C57BL/6J-Rabl3xm MGI:6441540
ht2
 		Rabl3xm/Rabl3em1Btlr C57BL/6J-Rabl3xm Rabl3em1Btlr MGI:6441542


Genotype
MGI:6441540
hm1
Allelic
Composition		 Rabl3xm/Rabl3xm
Genetic
Background		 C57BL/6J-Rabl3xm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabl3xm mutation (0 available); any Rabl3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell morphology ( J:287198 )
• increased CD44 expression in CD8+ T cells
abnormal T cell number ( J:287198 )
• increased CD4+ to CD8+ T cell ratio
• reduced CD3+ T cell frequencies
• increased B cell to T cell ratio

immune system
abnormal T cell morphology ( J:287198 )
• increased CD44 expression in CD8+ T cells
abnormal T cell number ( J:287198 )
• increased CD4+ to CD8+ T cell ratio
• reduced CD3+ T cell frequencies
• increased B cell to T cell ratio




Genotype
MGI:6441542
ht2
Allelic
Composition		 Rabl3xm/Rabl3em1Btlr
Genetic
Background		 C57BL/6J-Rabl3xm Rabl3em1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabl3em1Btlr mutation (0 available); any Rabl3 mutation (18 available)
Rabl3xm mutation (0 available); any Rabl3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

growth/size/body
decreased birth body size ( J:287198 )
• 30% smaller than WT littermates

hematopoietic system
hematopoietic system phenotype ( J:287198 )
N
• normal numbers of monocytes, platelets and neutrophils

immune system

mortality/aging
prenatal lethality, incomplete penetrance ( J:287198 )
• slightly lower than expected Mendelian ratio




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory