Phenotypes associated with this allele

• Allele Symbol: Tuba4a^m1Frla
• Allele Name: mutation 1, Francois Lanza
• Allele ID: MGI:6441799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tuba4a^m1Frla/Tuba4a^m1Frla	BALB/c-Tuba4a^m1Frla	MGI:6441801

Genotype
MGI:6441801

hm1

• Allelic Composition: Tuba4a^m1Frla/Tuba4a^m1Frla
• Genetic Background: BALB/c-Tuba4a^m1Frla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal megakaryocyte differentiation ( J:286522 )

• normal distribution of stage I-III MKs in bone marrow

• more compact demarcation membrane in 30% of stage III bone marrow MKs

• inability of stage III bone marrow MKs to extend well-developed proplatelets

hematopoietic system

abnormal megakaryocyte differentiation ( J:286522 )

• normal distribution of stage I-III MKs in bone marrow

• more compact demarcation membrane in 30% of stage III bone marrow MKs

• inability of stage III bone marrow MKs to extend well-developed proplatelets

abnormal platelet morphology ( J:286522 )

• reduction in number of MT coils in marginal band

thrombocytopenia ( J:286522 )

• 21% reduction in platelet count

abnormal platelet shape ( J:286522 )

• spherical

increased mean platelet volume ( J:286522 )

• 143% of wild-type MPV