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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fam151aem1Jkn
endonuclease-mediated mutation 1, Ian J Jackson
MGI:6442001
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fam151aem1Jkn/Fam151aem1Jkn involves: C57BL/6J MGI:6442005
cx2
 		Fam151aem1Jkn/Fam151aem1Jkn
Fam151btm1b(EUCOMM)Hmgu/Fam151btm1b(EUCOMM)Hmgu 		involves: C57BL/6J * C57BL/6N * C57BL/6NTac MGI:6442006


Genotype
MGI:6442005
hm1
Allelic
Composition		 Fam151aem1Jkn/Fam151aem1Jkn
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam151aem1Jkn mutation (0 available); any Fam151a mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:284934 )
N
• normal heart weight

vision/eye
vision/eye phenotype ( J:284934 )
N
• ERG analysis found no decrease in retinal response to a light stimulus: normal a-waves and b-waves at age one year
• normal gross retinal morphology, no loss of photoreceptor cells nor increased GFAP staining




Genotype
MGI:6442006
cx2
Allelic
Composition		 Fam151aem1Jkn/Fam151aem1Jkn
Fam151btm1b(EUCOMM)Hmgu/Fam151btm1b(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6J * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam151aem1Jkn mutation (0 available); any Fam151a mutation (35 available)
Fam151btm1b(EUCOMM)Hmgu mutation (1 available); any Fam151b mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased photoreceptor outer segment number ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
short photoreceptor outer segment ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
photoreceptor outer segment degeneration ( J:284934 )
• reduced layer thickness at age P21

pigmentation
abnormal retina pigmentation ( J:284934 )
• patchy pigmentation at age P21

vision/eye
decreased photoreceptor outer segment number ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
short photoreceptor outer segment ( J:284934 )
• severely reduced layer thickness and number of photoreceptor cell nuclei at age P21
photoreceptor outer segment degeneration ( J:284934 )
• reduced layer thickness at age P21
abnormal retina pigmentation ( J:284934 )
• patchy pigmentation at age P21




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory