About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dhx15em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6442536
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dhx15em1(IMPC)Tcp/Dhx15em1(IMPC)Tcp C57BL/6NCrl-Dhx15em1(IMPC)Tcp/Cmmr MGI:7414863
ht2
Dhx15em1(IMPC)Tcp/Dhx15+ C57BL/6NCrl-Dhx15em1(IMPC)Tcp/Cmmr MGI:7414862


Genotype
MGI:7414863
hm1
Allelic
Composition
Dhx15em1(IMPC)Tcp/Dhx15em1(IMPC)Tcp
Genetic
Background
C57BL/6NCrl-Dhx15em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx15em1(IMPC)Tcp mutation (2 available); any Dhx15 mutation (41 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Dhx15em1(IMPC)Tcp/Dhx15em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro fail to hatch from the zona pellucida.

embryo
• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida after 3 days in culture

mortality/aging
• blastocyst-like embryos are present in expected Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo




Genotype
MGI:7414862
ht2
Allelic
Composition
Dhx15em1(IMPC)Tcp/Dhx15+
Genetic
Background
C57BL/6NCrl-Dhx15em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx15em1(IMPC)Tcp mutation (2 available); any Dhx15 mutation (41 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system

hematopoietic system

nervous system

vision/eye
IMPC - TCP





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory