Phenotypes associated with this allele

• Allele Symbol: Ccdc198^{em1(IMPC)Ccpcz}
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:6442544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc198^em1(IMPC)Ccpcz/Ccdc198^em1(IMPC)Ccpcz	C57BL/6NCrl-Ccdc198^em1(IMPC)Ccpcz/Ph	MGI:7414815

Genotype
MGI:7414815

hm1

• Allelic Composition: Ccdc198^{em1(IMPC)Ccpcz}/Ccdc198^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6NCrl-Ccdc198^{em1(IMPC)Ccpcz}/Ph

Data Sources

IMPC Data for Ccdc198

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased food intake ( J:337480 )

♂ • after warm-cold challenge, 10-week-old males show a significantly higher food intake during nighttime cold challenge than wild-type males

decreased vertical activity ( J:337480 )

• at P70, males show significantly less daytime, nighttime, and 24-hr average Z-activity (beam breaks/h) in metabolic cages than wild-type males

• after warm-cold challenge, 10-week-old males show a significantly lower Z-activity during daytime cold (4 degrees Celsius) challenge than wild-type males

• after warm-cold challenge, 10-week-old females show a significantly lower nighttime and 24-hr average Z-activity than wild-type females

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

growth/size/body

decreased lean body mass ( J:337480 )

♂ • on a standard chow diet, 10-week-old males show a significantly lower mean lean body mass than age-matched wild-type males

♂ • however, mean lean body mass is not significantly altered in 10-week-old females

decreased body weight ( J:337480 )

• on a standard chow diet, 10-week-old males show a significantly lower mean body weight than age-matched wild-type males; mean body weight is only slightly decreased in 10-week-old females

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

decreased eosinophil cell number ( J:337480 )

♀ • females, but not males, show a significantly lower eosinophil count than age-matched wild-type controls

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:337480 )

N • 18-week-old males and females show normal serum ferritin, ghrelin and leptin levels relative to age-matched wild-type controls

N • 14-week-old males and females show a normal urine albumin to creatinine ratio relative to age-matched wild-type controls

increased energy expenditure ( J:337480 )

♂ • after warm-cold challenge, 10-week-old males show a significant increase in daytime and 24-hr average energy expenditure than wild-type males

immune system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

decreased eosinophil cell number ( J:337480 )

♀ • females, but not males, show a significantly lower eosinophil count than age-matched wild-type controls

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

limbs/digits/tail

abnormal digit morphology ( J:211773 )

IMPC - CCP-IMG

reproductive system

abnormal epididymis morphology ( J:211773 )

♂

IMPC - CCP-IMG

respiratory system

decreased lung elastance ( J:211773 )

IMPC - CCP-IMG

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - CCP-IMG

microphthalmia ( J:211773 )

♀

IMPC - CCP-IMG