|
Allele Symbol Allele Name Allele ID |
Fis1tm1.1Itl targeted mutation 1.1, inGenious Targeting Laboratory MGI:6444618 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice
|
|
• increased GFP-LC3 puncta containing mitochondria in the soleus of sedentary mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• following 3 consecutive days of exercise to exhaustion, mice exhibit increased body temperature, increased plasma cytokines (IL-6, IL-12p40, IL-13, KC, RANTES and IFNbeta), disorganized Z-band in soleus muscle, and delayed onset muscle ultrastructure change in soleus muscle compared with wild-type mice
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• following 3 consecutive days of exercise to exhaustion
|
|
• loss of cristae and low matric density
|
|
• prior to and after exercise
|
|
• impaired respiratory chain function in slow muscle with reduced Complex I protein levels
|
|
• in the soleus of mice exercised to exhausting on consecutive days
|
|
• delayed onset muscle ultrastructure change in the soleus of mice exercised to exhausting on consecutive days
• however, there are no ultrastructure changes in the gastrocnemius following exercise
|
|
• following 3 consecutive days of exercise to exhaustion, mice exhibit increased body temperature, increased plasma cytokines (IL-6, IL-12p40, IL-13, KC, RANTES and IFNbeta), disorganized Z-band in soleus muscle, and delayed onset muscle ultrastructure change in soleus muscle compared with wild-type mice
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
|
• in mice exercised to exhausting on consecutive days
• however, plasma cytokine levels return to normal after exercise exhaustion
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
|
|
|
||
Analysis Tools