Phenotypes associated with this allele

• Allele Symbol: Drg2^tm1Jgwp
• Allele Name: targeted mutation 1, Jeong Woo Park
• Allele ID: MGI:6444651
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drg2^tm1Jgwp/Drg2^tm1Jgwp	B6.129-Drg2^tm1Jgwp	MGI:6444804

Genotype
MGI:6444804

hm1

• Allelic Composition: Drg2^tm1Jgwp/Drg2^tm1Jgwp
• Genetic Background: B6.129-Drg2^tm1Jgwp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:290483 )

behavior/neurological

behavior/neurological phenotype ( J:291077 )

N • mice exhibit normal motor learning and memory

increased anxiety-related response ( J:290483 )

• mice spend less time in the open arms of an elevated plus-maze

abnormal motor coordination/balance ( J:291077 )

• mice exhibit inability to stand on the inclined plane at P4, P6, and P8 unlike wild-type mice

• however, mice exhibit normal performance at P10

impaired coordination ( J:290483 )

• at 6 and 12 weeks on a rotarod

• however, rotarod performance at 40 weeks is normal

skeleton

decreased length of long bones ( J:290483 )

• however, bone density is normal

decreased bone mineralization ( J:290483 )

• in the skull

decreased bone ossification ( J:290483 )

• increases in unossified areas in the anterior fontanel

growth/size/body

decreased body size ( J:290483 )

• at birth, persisting into adulthood

decreased body weight ( J:290483 )

nervous system

abnormal synaptic dopamine release ( J:291077 )

• decreased release of nigrostriatal dopamine