About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Btnl1em1Ahay
endonuclease-mediated mutation 1, Adrian C Hayday
MGI:6445624
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Btnl1em1Ahay/Btnl1em1Ahay Not Specified MGI:6446215


Genotype
MGI:6446215
hm1
Allelic
Composition		 Btnl1em1Ahay/Btnl1em1Ahay
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1em1Ahay mutation (0 available); any Btnl1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory