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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Btnl1em1Ahay
endonuclease-mediated mutation 1, Adrian C Hayday
MGI:6445624
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Btnl1em1Ahay/Btnl1em1Ahay Not Specified MGI:6446215


Genotype
MGI:6446215
hm1
Allelic
Composition		 Btnl1em1Ahay/Btnl1em1Ahay
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1em1Ahay mutation (0 available); any Btnl1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut

immune system
decreased gamma-delta intraepithelial T cell number ( J:236526 )
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut
• Normal TCRVgamma7- IEL number in the gut
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:236526 )
• significantly increased TCRbeta+ CD8alpha+ intraepithelial lymphocyte (IEL) level in the gut




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory