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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfe2tm1.1Hlpa
targeted mutation 1.1, Heike Luise Pahl
MGI:6446746
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Nfe2tm1.1Hlpa/? involves: 129 * C57BL/6 MGI:6446751


Genotype
MGI:6446751
ot1
Allelic
Composition		 Nfe2tm1.1Hlpa/?
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfe2tm1.1Hlpa mutation (0 available); any Nfe2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased acute myeloid leukemia incidence ( J:275444 )
• acute myeloid leukemia sometimes accompanies the development of granulocytic sarcoma
increased myeloid sarcoma incidence ( J:275444 )
• 23% of mice develop a granulocytic sarcoma with or without an accompanying acute myeloid leukemia (AML)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory