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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gab3em1Khoe
endonuclease-mediated mutation 1, Kasper Hoebe
MGI:6446855
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gab3em1Khoe/Gab3em1Khoe C57BL/6-Gab3em1Khoe MGI:6446899


Genotype
MGI:6446899
hm1
Allelic
Composition
Gab3em1Khoe/Gab3em1Khoe
Genetic
Background
C57BL/6-Gab3em1Khoe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab3em1Khoe mutation (0 available); any Gab3 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• in spiral artery walls at gestational day 12.5 and 18.5
• significant expansion of trophoblasts in labyrinth and junctional zone of placentas, leading to an overall increase in labyrinth, junctional zone and overall placenta depth at gestational day 18.5
• discontinuous trophoblast invasion of decidua basalis with select areas showing deep invasion reaching uterine wall at gestational day 18.5
• ~70% reduction in CD45+, CD122+ CD3-, DBA- NK1.1+ NK cell frequency at gestational day 8.5
• reduction in tissue resident NK (trNK) cells at implantation sites at gestation day 8.5
• normal ILC1 and conventional NK (cNK) cell numbers at implantation sites at gestational day 8.5

endocrine/exocrine glands
• ~70% reduction in CD45+, CD122+ CD3-, DBA- NK1.1+ NK cell frequency at gestational day 8.5
• reduction in tissue resident NK (trNK) cells at implantation sites at gestation day 8.5
• normal ILC1 and conventional NK (cNK) cell numbers at implantation sites at gestational day 8.5

hematopoietic system
• ~70% reduction in CD45+, CD122+ CD3-, DBA- NK1.1+ NK cell frequency at gestational day 8.5
• reduction in tissue resident NK (trNK) cells at implantation sites at gestation day 8.5
• normal ILC1 and conventional NK (cNK) cell numbers at implantation sites at gestational day 8.5
• reduced Ly49G2+ NK cell frequency
• impaired IL-2 and IL-15 induced priming and proliferation
• impaired ability to clear injected melanoma tumor cells (higher tumor burden)
• impaired ability to clear beta2M-deficient splenocytes

immune system
N
• normal frequency and development of B cells and CD8+ and CD4+ T cells
• normal NK cell frequency in spleen and bone marrow
• normal NK cell maturation and expression of activating (Ly49D, Ly49H) and inhibiting Ly49 receptors
• ~70% reduction in CD45+, CD122+ CD3-, DBA- NK1.1+ NK cell frequency at gestational day 8.5
• reduction in tissue resident NK (trNK) cells at implantation sites at gestation day 8.5
• normal ILC1 and conventional NK (cNK) cell numbers at implantation sites at gestational day 8.5
• reduced Ly49G2+ NK cell frequency
• impaired IL-2 and IL-15 induced priming and proliferation
• impaired ability to clear injected melanoma tumor cells (higher tumor burden)
• impaired ability to clear beta2M-deficient splenocytes

reproductive system
• ~70% reduction in CD45+, CD122+ CD3-, DBA- NK1.1+ NK cell frequency at gestational day 8.5
• reduction in tissue resident NK (trNK) cells at implantation sites at gestation day 8.5
• normal ILC1 and conventional NK (cNK) cell numbers at implantation sites at gestational day 8.5
• drastically increased rate

mortality/aging
N
• viable





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory