Analysis Tools
mortality/aging
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• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls
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immune system
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• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
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• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
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• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
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• MHV-infected males and females show reduced hepatic and spleen B cell numbers
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• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
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• MHV-infected females show reduced hepatic CD4+ T cells
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• MHV-infected males show reduced recruitment of macrophages to the liver
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• at 3 days post MHV-infection, inflammation is moderately reduced in females compared to controls, but not in males
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• mice are highly susceptible to mouse hepatitis virus-A59 (MHV)
• males show greater susceptibility than females
• females and males infected with MHV show elevated spleen viral burden at both high and lower doses of MHV, however hepatic viral burden is similar in males and females
• viral burden and liver damage are elevated in females at a lower dose of MHV but not in males which exhibit saturated hepatic infection
• bone marrow-derived macrophages are more susceptible to MHV infection
• in splenocyte cultures, MHV infects macrophages, neutrophils, dendritic cells and B cells but not CD4+ or CD8+ T cells
• B cells from both male and female mice are highly susceptible to MHV infection
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• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls
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hematopoietic system
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• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
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• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
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• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
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• MHV-infected males and females show reduced hepatic and spleen B cell numbers
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• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
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• MHV-infected females show reduced hepatic CD4+ T cells
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• MHV-infected males show reduced recruitment of macrophages to the liver
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homeostasis/metabolism
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• females, but not males, infected with MHV exhibit increased serum alanine aminotransferase levels
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liver/biliary system
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• females, but not males, infected with MHV exhibit higher levels of liver damage than controls
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• by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males
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pale liver
(
J:291868
)
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• mice infected with an intermediate viral dose of MHV exhibit liver pallor
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