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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Skic3em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6449032
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Skic3em1(IMPC)Tcp/Skic3em1(IMPC)Tcp C57BL/6NCrl-Skic3em1(IMPC)Tcp/Cmmr MGI:7472228
ht2
 		Skic3em1(IMPC)Tcp/Skic3+ C57BL/6NCrl-Skic3em1(IMPC)Tcp/Cmmr MGI:7472227


Genotype
MGI:7472228
hm1
Allelic
Composition		 Skic3em1(IMPC)Tcp/Skic3em1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Skic3em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skic3em1(IMPC)Tcp mutation (2 available); any Skic3 mutation (81 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Skic3em1(IMPC)Tcp/Skic3em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and show severe developmental delay as small egg cyclinders with poorly organized extra embryonic tissues.

embryo
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5
abnormal egg cylinder morphology ( J:279207 )
• a small egg cylinder is observed at E7.5
disorganized extraembryonic tissue ( J:279207 )
• extraembryonic tissues are poorly organized at E7.5

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos show a severe developmental delay at E7.5
decreased embryo size ( J:279207 )
• embryos are much smaller than controls at E7.5

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )
• homozygous embryos can be recovered at E7.5 (8% versus expected 25%, n=38); no homozygous embryos are recovered at E9.5




Genotype
MGI:7472227
ht2
Allelic
Composition		 Skic3em1(IMPC)Tcp/Skic3+
Genetic
Background		 C57BL/6NCrl-Skic3em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skic3em1(IMPC)Tcp mutation (2 available); any Skic3 mutation (81 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body
enlarged urinary bladder ( J:211773 )
IMPC - TCP

hematopoietic system

homeostasis/metabolism

renal/urinary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory