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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Top2bem1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6449041
Summary 2 genotypes


Genotype
MGI:7415129
hm1
Allelic
Composition		 Top2bem1(IMPC)Mbp/Top2bem1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Top2bem1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2bem1(IMPC)Mbp mutation (1 available); any Top2b mutation (91 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:211773 )
IMPC - UCD

digestive/alimentary system
cleft palate ( J:211773 )
IMPC - UCD

embryo

growth/size/body
cleft palate ( J:211773 )
IMPC - UCD
abnormal head shape ( J:211773 )
IMPC - UCD
embryonic growth retardation ( J:211773 )
IMPC - UCD

homeostasis/metabolism
edema ( J:211773 )
IMPC - UCD

mortality/aging




Genotype
MGI:7415128
ht2
Allelic
Composition		 Top2bem1(IMPC)Mbp/Top2b+
Genetic
Background		 C57BL/6NCrl-Top2bem1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top2bem1(IMPC)Mbp mutation (1 available); any Top2b mutation (91 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
small spleen ( J:211773 )
IMPC - UCD

immune system
small spleen ( J:211773 )
IMPC - UCD

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory