Phenotypes associated with this allele

• Allele Symbol: Opn3^{tm2c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6449231
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Opn3^tm2c(EUCOMM)Wtsi/Opn3^tm2c(EUCOMM)Wtsi Tg(Rax-cre)1Zkoz/0	involves: C57BL/6N	MGI:6457284
cn2	Opn3^tm2c(EUCOMM)Wtsi/Opn3^tm2c(EUCOMM)Wtsi Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6N * FVB	MGI:6457283
cn3	Opn3^tm2c(EUCOMM)Wtsi/Opn3^tm2c(EUCOMM)Wtsi Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6N * FVB/NJ	MGI:6457282

Genotype
MGI:6457284

cn1

• Allelic Composition: Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi}; Tg(Rax-cre)1Zkoz/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:287419 )

N • mice exhibit normal adaptive thermogenesis under any lighting condition

Genotype
MGI:6457283

cn2

• Allelic Composition: Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi}; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: C57BL/6N * FVB

adipose tissue

adipose tissue phenotype ( J:287419 )

N • mice exhibit normal adaptive thermogenesis under any lighting condition

Genotype
MGI:6457282

cn3

• Allelic Composition: Opn3^{tm2c(EUCOMM)Wtsi}/Opn3^{tm2c(EUCOMM)Wtsi}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6N * FVB/NJ

adipose tissue

abnormal beige fat cell morphology ( J:287419 )

• low beige content in inguinal white adipose tissue

abnormal white fat cell size ( J:287419 )

• larger size distribution

abnormal adipose tissue physiology ( J:287419 )

• fed and fasted, cold-exposed mice impaired fat mobilization compared with control mice

homeostasis/metabolism

impaired adaptive thermogenesis ( J:287419 )

• reduced core body temperature following cold-exposure under full spectrum lighting

• however, mice raised without 480 nm light exhibit normal cold exposure response and tail temperatures are normal

abnormal circulating glycerol level ( J:287419 )

• unlike wild-type mice, fasted mice exhibit reduced elevation of serum glycerol compared with fed mice

decreased core body temperature ( J:287419 )

• following cold-exposure