Phenotypes associated with this allele

• Allele Symbol: Mlkl^em1Hbz
• Allele Name: endonuclease-mediated mutation 1, Haibing Zhang
• Allele ID: MGI:6449640
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Casp8^em1Hbz/Casp8^em1Hbz Mlkl^em1Hbz/Mlkl^em1Hbz	involves: C57BL/6	MGI:7573092

Genotype
MGI:7573092

cx1

• Allelic Composition: Casp8^em1Hbz/Casp8^em1Hbz; Mlkl^em1Hbz/Mlkl^em1Hbz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

hematopoietic system

enlarged spleen ( J:342732 )

increased granulocyte number ( J:342732 )

• increased CD11b+ granulocytes in spleen

• normal in bone marrow

increased CD11b-high dendritic cell number ( J:342732 )

• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow

increased macrophage cell number ( J:342732 )

• in spleen

• normal in bone marrow

decreased leukocyte cell number ( J:342732 )

• decreased white blood cell number in peripheral blood

• normal monocyte and granulocyte numbers in peripheral blood

decreased lymphocyte cell number ( J:342732 )

• in peripheral blood

decreased B cell number ( J:342732 )

• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood

decreased mature B cell number ( J:342732 )

• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in peripheral blood

decreased T cell number ( J:342732 )

• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood

• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in peripheral blood

growth/size/body

enlarged spleen ( J:342732 )