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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripk1em1Hbz
endonuclease-mediated mutation 1, Haibing Zhang
MGI:6449644
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573098


Genotype
MGI:7573098
cx1
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Ripk1em1Hbz mutation (0 available); any Ripk1 mutation (33 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

immune system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory