Phenotypes associated with this allele

• Allele Symbol: H6pd^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6449815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	H6pd^tm1c(EUCOMM)Wtsi/H6pd^tm1c(EUCOMM)Wtsi Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6N * FVB/NJ	MGI:6449844

Genotype
MGI:6449844

cn1

• Allelic Composition: H6pd^{tm1c(EUCOMM)Wtsi}/H6pd^{tm1c(EUCOMM)Wtsi}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased subcutaneous adipose tissue amount ( J:292236 )

• 34% reduction

decreased fat cell size ( J:292236 )

• 20% reduction

decreased epididymal fat pad weight ( J:292236 )

• 53% reduction; also reduced under fasting conditions

decreased mesenteric fat pad weight ( J:292236 )

• 62% reduction

homeostasis/metabolism

decreased fasting circulating glucose level ( J:292236 )

decreased circulating insulin level ( J:292236 )

• during GTT and under fasting conditions

decreased circulating free fatty acids level ( J:292236 )

• under both fed and fasting states

improved glucose tolerance ( J:292236 )

• decreased glucose levels during GTT

increased insulin sensitivity ( J:292236 )

• improved glucose clearance during ITT

abnormal corticosterone level ( J:292236 )

• decreased in epididymal and subcutaneous fat

• normal plasma levels

decreased lipogenesis ( J:292236 )

• in epididymal and subcutaneous fat

impaired lipolysis ( J:292236 )

• in epididymal fat under both fed and fasting states

integument

decreased subcutaneous adipose tissue amount ( J:292236 )

• 34% reduction

growth/size/body

growth/size/body region phenotype ( J:292236 )

N • normal weight gain

cardiovascular system

cardiovascular system phenotype ( J:292236 )

N • normal mean systolic blood pressure

behavior/neurological

behavior/neurological phenotype ( J:292236 )

N • normal food intake