All Phenotypes Nubp2<tm1c(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J	MGI:6452819
cn2	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0	involves: C57BL/6	MGI:6450919

Allelic Composition	Nubp2^{tm1c(EUCOMM)Hmgu}/Nubp2^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ Tg(Wnt1-GAL4)11Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Nubp2^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Nubp2 mutation (17 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

increased cranial neural crest cell apoptosis ( J:284772 )

• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

cellular

increased cranial neural crest cell apoptosis ( J:284772 )

• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small frontonasal prominence ( J:284772 )

• at E15.5

small mandibular prominence ( J:284772 )

• at E15.5

small maxillary prominence ( J:284772 )

• at E15.5

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

growth/size/body

absent nasal capsule ( J:284772 )

abnormal face development ( J:284772 )

• undersized facial primordia at E10.5

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

midline facial cleft ( J:284772 )

• at E15.5

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

embryo

abnormal head mesenchyme morphology ( J:284772 )

• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice

• however, there is no difference in centriole number

digestive/alimentary system

abnormal stomodeum morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

nervous system

abnormal brain morphology ( J:284772 )

• brain is shifted rostrally

respiratory system

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

skeleton

absent nasal capsule ( J:284772 )

nasal septum cartilage hypoplasia ( J:284772 )

• severe

taste/olfaction

abnormal olfactory epithelium morphology ( J:284772 )

• olfactory epithelium is continuous with the oral cavity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24