Phenotypes associated with this allele

• Allele Symbol: Myocd^em1Blk
• Allele Name: endonuclease-mediated mutation 1, Brian L Black
• Allele ID: MGI:6450718
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myocd^em1Blk/Myocd^tm1.1Msp	involves: 129	MGI:6450809

Genotype
MGI:6450809

ht1

• Allelic Composition: Myocd^em1Blk/Myocd^tm1.1Msp
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:283803 )

• unlike mice homozygous for Myocd ^tm1.1Msp, mice survive to birth but die by 1 week of age

renal/urinary system

abnormal urinary bladder morphology ( J:283803 )

• thin bladder wall

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• little or no smooth muscle in the bladder wall

distended urinary bladder ( J:283803 )

• grossly dilated bladder at P1

cardiovascular system

cardiovascular system phenotype ( J:283803 )

N • no gross cardiac defects

muscle

abnormal urinary bladder detrusor smooth muscle morphology ( J:283803 )

• little or no smooth muscle in the bladder wall

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital megabladder		DOID:0112014	OMIM:618719	J:283803