About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup85tm1.1Yter
targeted mutation 1.1, Yuya Terashima
MGI:6451077
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lyz2tm1(cre)Ifo/0
Nup85tm1.1Yter/Nup85tm1.1Yter 		involves: 129P2/OlaHsd * C57BL/6 MGI:6451098
cn2
 		Nup85tm1.1Yter/Nup85tm1.1Yter
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:6451097


Genotype
MGI:6451098
cn1
Allelic
Composition		 Lyz2tm1(cre)Ifo/0
Nup85tm1.1Yter/Nup85tm1.1Yter
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nup85tm1.1Yter mutation (0 available); any Nup85 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue

immune system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue

neoplasm
decreased tumor growth/size ( J:292726 )
• reduced size of induced lung tumors




Genotype
MGI:6451097
cn2
Allelic
Composition		 Nup85tm1.1Yter/Nup85tm1.1Yter
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup85tm1.1Yter mutation (0 available); any Nup85 mutation (48 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue
• reduced CD206+ proportion of M2 macrophages in induced tumor tissue
decreased Ly6C high monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue
decreased Ly6C low monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue

immune system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue
• reduced CD206+ proportion of M2 macrophages in induced tumor tissue
decreased Ly6C high monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue
decreased Ly6C low monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue

neoplasm
decreased tumor growth/size ( J:292726 )
• reduced size of induced tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory