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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup85tm1.1Yter
targeted mutation 1.1, Yuya Terashima
MGI:6451077
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lyz2tm1(cre)Ifo/0
Nup85tm1.1Yter/Nup85tm1.1Yter 		involves: 129P2/OlaHsd * C57BL/6 MGI:6451098
cn2
 		Nup85tm1.1Yter/Nup85tm1.1Yter
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:6451097


Genotype
MGI:6451098
cn1
Allelic
Composition		 Lyz2tm1(cre)Ifo/0
Nup85tm1.1Yter/Nup85tm1.1Yter
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Nup85tm1.1Yter mutation (0 available); any Nup85 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue

immune system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue

neoplasm
decreased tumor growth/size ( J:292726 )
• reduced size of induced lung tumors




Genotype
MGI:6451097
cn2
Allelic
Composition		 Nup85tm1.1Yter/Nup85tm1.1Yter
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup85tm1.1Yter mutation (0 available); any Nup85 mutation (48 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue
• reduced CD206+ proportion of M2 macrophages in induced tumor tissue
decreased Ly6C high monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue
decreased Ly6C low monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue

immune system
decreased macrophage cell number ( J:292726 )
• fewer macrophages in induced tumor tissue
• reduced CD206+ proportion of M2 macrophages in induced tumor tissue
decreased Ly6C high monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue
decreased Ly6C low monocyte number ( J:292726 )
• fewer monocytes in induced tumor tissue

neoplasm
decreased tumor growth/size ( J:292726 )
• reduced size of induced tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory