Phenotypes associated with this allele

• Allele Symbol: Cdk13^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6451101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk13^tm1d(EUCOMM)Hmgu/Cdk13^tm1d(EUCOMM)Hmgu	involves: C57BL/6N * C57BL/6NTac	MGI:6451682

Genotype
MGI:6451682

hm1

• Allelic Composition: Cdk13^{tm1d(EUCOMM)Hmgu}/Cdk13^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:291583 )

• increase in mortality before E12.5

embryo

embryonic growth retardation ( J:291583 )

• severe growth retardation, with all embryos being growth retarded at E12.5, E13.5, and E14.5

decreased embryo size ( J:291583 )

growth/size/body

abnormal facial morphology ( J:291583 )

• midline orofacial deficiency in 60.5% of E12.5-E14.5 mutants

midface hypoplasia ( J:291583 )

• hypoplasia of midfacial structures

midline facial cleft ( J:291583 )

embryonic growth retardation ( J:291583 )

• severe growth retardation, with all embryos being growth retarded at E12.5, E13.5, and E14.5

decreased embryo size ( J:291583 )

cardiovascular system

small heart ( J:291583 )

abnormal heart ventricle morphology ( J:291583 )

• severe ventricle deficiency

pericardial effusion ( J:291583 )

• pericardial effusion in 60.5% of E12.5-E14.5 mutants

craniofacial

abnormal facial morphology ( J:291583 )

• midline orofacial deficiency in 60.5% of E12.5-E14.5 mutants

midface hypoplasia ( J:291583 )

• hypoplasia of midfacial structures

midline facial cleft ( J:291583 )

homeostasis/metabolism

pericardial effusion ( J:291583 )

• pericardial effusion in 60.5% of E12.5-E14.5 mutants

liver/biliary system

abnormal liver development ( J:291583 )

• liver show abrogated liver lobes arrangement

small liver ( J:291583 )

renal/urinary system

abnormal kidney development ( J:291583 )

• kidneys do not follow right left kidney asymmetry

small kidney ( J:291583 )