About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Unc80em1Dren
endonuclease-mediated mutation 1, Dejian Ren
MGI:6451179
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Unc80em1Dren/Unc80em1Dren C57BL/6J-Unc80em1Dren MGI:6451187


Genotype
MGI:6451187
hm1
Allelic
Composition		 Unc80em1Dren/Unc80em1Dren
Genetic
Background		 C57BL/6J-Unc80em1Dren
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Unc80em1Dren mutation (0 available); any Unc80 mutation (184 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:291847 )
• no pups survive beyond 24 hours of birth

respiratory system
apnea ( J:291847 )
• pups exhibit severe apnea

nervous system
abnormal nervous system electrophysiology ( J:291847 )
• cultured hippocampal neurons exhibit decreased NALCN-dependent sodium leak current
• lowering extracellular calcium concentration from 2 to 0.1 mM does not lead to an obvious increase of NALCN-dependent sodium leak current in hippocampal neurons as in wild-type neurons
abnormal channel response ( J:291847 )
• cultured hippocampal neurons exhibit decreased NALCN-dependent sodium leak current




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory