Phenotypes associated with this allele

• Allele Symbol: Unc80^em2Dren
• Allele Name: endonuclease-mediated mutation 2, Dejian Ren
• Allele ID: MGI:6451181
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Unc80^em2Dren/Unc80^em2Dren	involves: C57BL/6J * SJL/J	MGI:6451188

Genotype
MGI:6451188

hm1

• Allelic Composition: Unc80^em2Dren/Unc80^em2Dren
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:291847 )

• no pups survive past P1

nervous system

abnormal nervous system electrophysiology ( J:291847 )

• cultured hippocampal neurons exhibit a larger NALCN-dependent sodium leak current than in wild-type neurons and it is increased by lowering extracellular calcium concentrations like in wild-type mice

abnormal channel response ( J:291847 )

• cultured hippocampal neurons exhibit a larger NALCN-dependent sodium leak current than in wild-type neurons

respiratory system

apnea ( J:291847 )

• newborn pups exhibit severe apnea