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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld4tm1.1Nemz
targeted mutation 1.1, David Nemazeez
MGI:6451772
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lyz2tm1(cre)Ifo/0
Pld4tm1.1Nemz/Pld4tm1.1Nemz 		involves: 129 * 129P2/OlaHsd * C57BL/6J MGI:6452100
cn2
 		Pld4tm1.1Nemz/Pld4tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0 		involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:6452099


Genotype
MGI:6452100
cn1
Allelic
Composition		 Lyz2tm1(cre)Ifo/0
Pld4tm1.1Nemz/Pld4tm1.1Nemz
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Pld4tm1.1Nemz mutation (0 available); any Pld4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:281205 )
N
• no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages




Genotype
MGI:6452099
cn2
Allelic
Composition		 Pld4tm1.1Nemz/Pld4tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.1Nemz mutation (0 available); any Pld4 mutation (26 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

immune system
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory