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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld4tm1.2Nemz
targeted mutation 1.2, David Nemazeez
MGI:6451773
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pld4tm1.2Nemz/Pld4tm1.2Nemz B6.129(Cg)-Pld4tm1.1Nemz MGI:6452095
cx2
 		Pld3em1Nemz/Pld3em1Nemz
Pld4tm1.2Nemz/Pld4tm1.2Nemz 		B6.Cg-Pld3em1Nemz Pld4tm1.1Nemz MGI:6452092
cx3
 		Ifngtm1Ts/Ifngtm1Ts
Pld4tm1.2Nemz/Pld4tm1.2Nemz 		involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:6452102
cx4
 		Pld4tm1.2Nemz/Pld4tm1.2Nemz
Rag1tm1Mom/Rag1tm1Mom 		involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:6452104
cx5
 		Pld4tm1.2Nemz/Pld4tm1.2Nemz
Tlr9M7Btlr/Tlr9M7Btlr 		involves: 129 * C57BL/6J * FVB/N MGI:6452105


Genotype
MGI:6452095
hm1
Allelic
Composition		 Pld4tm1.2Nemz/Pld4tm1.2Nemz
Genetic
Background		 B6.129(Cg)-Pld4tm1.1Nemz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:281205 )
• in peritoneum
abnormal leukocyte cell number ( J:281205 )
• elevated blood monocyte count
• splenic dendritic cell number
decreased B-1 B cell number ( J:281205 )
• in peritoneum
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages
• CD86 expression

homeostasis/metabolism
increased circulating CXCL10 level ( J:281205 )
• elevated plasma CXCL10 levels

immune system
immune system phenotype ( J:281205 )
N
• normal thioglycolate-elicited IL6 expression in macrophages in response to A-type CpG ODN 2216PS
abnormal leukocyte cell number ( J:281205 )
• elevated blood monocyte count
• splenic dendritic cell number
decreased B-1 B cell number ( J:281205 )
• in peritoneum
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages
• CD86 expression
increased circulating CXCL10 level ( J:281205 )
• elevated plasma CXCL10 levels

growth/size/body
enlarged spleen ( J:281205 )

mortality/aging
mortality/aging ( J:281205 )
N
• resistant to experimental autoimmune encephalomyelitis




Genotype
MGI:6452092
cx2
Allelic
Composition		 Pld3em1Nemz/Pld3em1Nemz
Pld4tm1.2Nemz/Pld4tm1.2Nemz
Genetic
Background		 B6.Cg-Pld3em1Nemz Pld4tm1.1Nemz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld3em1Nemz mutation (0 available); any Pld3 mutation (81 available)
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver inflammation ( J:281205 )
• severe liver inflammation leads to death between age P12 and P21
• macroscopic white areas of necrosis, regions of vesicular steatosis, hemophagocytosis and multinucleated hepatocytes
• infiltration by CD68+ myeloid cells at age P16
hepatic steatosis ( J:281205 )
• multinucleated hepatocytes

mortality/aging
preweaning lethality, complete penetrance ( J:281205 )
• severe liver inflammation leads to death between age P12 and P21

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:281205 )
N
• normal IFNA and IL1A levels at age P16
abnormal circulating chemokine level ( J:281205 )
• increased levels of CXCL10, CCL7 and CCL2 at age P16
increased circulating CXCL10 level ( J:281205 )
• increased levels of CXCL10 at P16

immune system
abnormal circulating chemokine level ( J:281205 )
• increased levels of CXCL10, CCL7 and CCL2 at age P16
increased circulating CXCL10 level ( J:281205 )
• increased levels of CXCL10 at P16
liver inflammation ( J:281205 )
• severe liver inflammation leads to death between age P12 and P21
• macroscopic white areas of necrosis, regions of vesicular steatosis, hemophagocytosis and multinucleated hepatocytes
• infiltration by CD68+ myeloid cells at age P16

hematopoietic system

growth/size/body
decreased birth body size ( J:281205 )




Genotype
MGI:6452102
cx3
Allelic
Composition		 Ifngtm1Ts/Ifngtm1Ts
Pld4tm1.2Nemz/Pld4tm1.2Nemz
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:281205 )
N
• no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

immune system

mortality/aging
increased susceptibility to induced morbidity/mortality ( J:281205 )
• sensitive to experimental autoimmune encephalomyelitis




Genotype
MGI:6452104
cx4
Allelic
Composition		 Pld4tm1.2Nemz/Pld4tm1.2Nemz
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

immune system
abnormal peritoneal macrophage morphology ( J:281205 )
• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages




Genotype
MGI:6452105
cx5
Allelic
Composition		 Pld4tm1.2Nemz/Pld4tm1.2Nemz
Tlr9M7Btlr/Tlr9M7Btlr
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4tm1.2Nemz mutation (0 available); any Pld4 mutation (26 available)
Tlr9M7Btlr mutation (1 available); any Tlr9 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:281205 )
N
• no elevation of expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages
• normal B-1 B cell and platelet numbers in peritoneum and normal NK T cell number
• normal marginal zone B cell number
• normal blood monocyte count

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:281205 )
N
• normal circulating interferon-gamma levels

immune system
immune system phenotype ( J:281205 )
N
• normal spleen
• normal plasma CXCL10 levels




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory