Phenotypes associated with this allele

• Allele Symbol: Zdhhc7^tm1.1Wqz
• Allele Name: targeted mutation 1.1, Weiqi Zhang
• Allele ID: MGI:6452490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc7^tm1.1Wqz/Zdhhc7^tm1.1Wqz	involves: 129S/Sv * C57BL/6J	MGI:6452491

Genotype
MGI:6452491

hm1

• Allelic Composition: Zdhhc7^tm1.1Wqz/Zdhhc7^tm1.1Wqz
• Genetic Background: involves: 129S/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial working memory ( J:293082 )

♀ • females, but not males, show more alterations in the spontaneous alterations test

decreased anxiety-related response ( J:293082 )

♀ • in the elevated plus maze, females spend more time in the open arms than wild-type mice

♀ • however, alternation between arms is no different and mice do not differ in relative open arm entries

decreased thigmotaxis ( J:293082 )

♀ • females, but not males, show more entries into the center during the open field test and spend more time there indicating reduced anxiety-related behavior

increased locomotor activity ( J:293082 )

♀ • females, but not males, travel a longer distance than wild-type mice in the open field test

♀ • however, mice show no differences in sociability, behavioral despair, and object relocation and recognition

nervous system

abnormal hippocampus morphology ( J:293082 )

• females, but not males, exhibit higher minimal hippocampal fractional anisotrophy values

• fibers in the hippocampal medioventral CA are shorter and remain predominately within the hippocampal medioventral area instead of projecting towards the medial prefrontal cortex

• shorter mean fiber length and shorter maximal fiber length

• however, fiber numbers do not differ

impaired synaptic plasticity ( J:293082 )

• synaptic plasticity is impaired at Schaffer collateral CA1 synapses of both females and males

abnormal CNS synaptic transmission ( J:293082 )

• after high-frequency stimulation, short-term potentiation is decreased in females and males

• however, no changes in basal excitability at Schaffer collateral CA1 synapses (no changes in input-output curves or paired-pulse facilitation) are seen

decreased excitatory postsynaptic current amplitude ( J:293082 )

♂ • the frequency of sEPSC is depressed in males

abnormal inhibitory postsynaptic currents ( J:293082 )

• sIPSC amplitudes are upregulated in females

• the frequencies of sIPSCs are downregulated in males

reduced long-term potentiation ( J:293082 )

• the magnitude of hippocampal LTP is decreased in females and males

abnormal miniature excitatory postsynaptic currents ( J:293082 )

• the frequency of mEPSC, but not sEPSC, is depressed in females

• the frequency of mEPSC is depressed in males

• the mESPC decay time is prolonged in males but not females

abnormal miniature inhibitory postsynaptic currents ( J:293082 )

• current decay of mIPSCs is slower in females, but not males

increased miniature inhibitory postsynaptic current amplitude ( J:293082 )

♀ • mIPSC amplitudes are upregulated in females

decreased miniature inhibitory postsynaptic current frequency ( J:293082 )

♂ • the frequencies of mIPSCs are downregulated in males