Phenotypes associated with this allele

• Allele Symbol: Zfyve1^em1Hbsh
• Allele Name: endonuclease-mediated mutation 1, H-B Shu
• Allele ID: MGI:6452968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfyve1^em1Hbsh/Zfyve1^em1Hbsh	C57BL/6J-Zfyve1^em1Hbsh	MGI:6453816

Genotype
MGI:6453816

hm1

• Allelic Composition: Zfyve1^em1Hbsh/Zfyve1^em1Hbsh
• Genetic Background: C57BL/6J-Zfyve1^em1Hbsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to viral infection induced morbidity/mortality ( J:292942 )

• in EMCV-infected mice, but not VSV-infected mice

immune system

decreased susceptibility to viral infection ( J:292942 )

• EMCV-infected mice exhibit reduced viral titers and decreased mortality compared with wild-type mice

• however, infected mice exhibit comparable IFN-beta and TNF serum levels as wild-type mice

decreased susceptibility to viral infection induced morbidity/mortality ( J:292942 )

• in EMCV-infected mice, but not VSV-infected mice