All Phenotypes Fam170a<em1Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fam170a^em1Osb
endonuclease-mediated mutation 1, Osaka University
MGI:6453859

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam170a^em1Osb/Fam170a^em1Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6454004
cx2	Fam170a^em1Osb/Fam170a^em1Osb Fam170b^em2Osb/Fam170b^em2Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6454006

Allelic Composition	Fam170a^em1Osb/Fam170a^em1Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam170a^em1Osb mutation (2 available); any Fam170a mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal sperm flagellum morphology ( J:293721 )

• bent in some sperm

abnormal sperm midpiece morphology ( J:293721 )

• bent in some sperm

oligozoospermia ( J:293721 )

• in the cauda epididymis

abnormal sperm head morphology ( J:293721 )

• with amorphous heads, bent neck and decapitation

abnormal acrosome morphology ( J:293721 )

absent sperm head ( J:293721 )

• in some sperm

abnormal spermatid morphology ( J:293721 )

• with delayed or abnormal spermatid elongation between stages IX and IXX and abnormal nuclear shapes

decreased hyperactivated sperm motility ( J:293721 )

decreased sperm progressive motility ( J:293721 )

endocrine/exocrine glands

decreased testis weight ( J:293721 )

• relative to body weight

growth/size/body

increased body weight ( J:293721 )

• in male mice

reproductive system

abnormal sperm flagellum morphology ( J:293721 )

• bent in some sperm

abnormal sperm midpiece morphology ( J:293721 )

• bent in some sperm

oligozoospermia ( J:293721 )

• in the cauda epididymis

abnormal sperm head morphology ( J:293721 )

• with amorphous heads, bent neck and decapitation

abnormal acrosome morphology ( J:293721 )

absent sperm head ( J:293721 )

• in some sperm

abnormal spermatid morphology ( J:293721 )

• with delayed or abnormal spermatid elongation between stages IX and IXX and abnormal nuclear shapes

decreased hyperactivated sperm motility ( J:293721 )

decreased sperm progressive motility ( J:293721 )

decreased testis weight ( J:293721 )

• relative to body weight

abnormal spermiogenesis ( J:293721 )

• with large atypical residual bodies at step 16

decreased litter size ( J:293721 )

• from male mice mated to wild-type mice

reduced male fertility ( J:293721 )

• male mice mated to wild-type mice produced smaller litters

Allelic Composition	Fam170a^em1Osb/Fam170a^em1Osb Fam170b^em2Osb/Fam170b^em2Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam170a^em1Osb mutation (2 available); any Fam170a mutation (26 available)
Fam170b^em2Osb mutation (2 available); any Fam170b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased litter size ( J:293721 )

• as in Fam170a^em1Osb homozygotes, from male mice mated to wild-type mice

reduced male fertility ( J:293721 )

• as in Fam170a^em1Osb homozygotes, male mice mated to wild-type mice produced smaller litters

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