All Phenotypes Tmprss12<em4Osb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmprss12^em4Osb
endonuclease-mediated mutation 4, Research Institute for Microbial Diseases, Osaka University
MGI:6455010

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss12^em4Osb/Tmprss12^em4Osb	involves: C57BL/6NJcl * DBA/2NJcl	MGI:6455013

Allelic Composition	Tmprss12^em4Osb/Tmprss12^em4Osb
Genetic Background	involves: C57BL/6NJcl * DBA/2NJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss12^em4Osb mutation (2 available); any Tmprss12 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

impaired sperm migration in female genital tract ( J:293874 )

asthenozoospermia ( J:293874 )

male infertility ( J:293874 )

impaired fertilization ( J:293874 )

• spermatozoa fail to fertilize cumulus-free oocytes in vitro and severely reduced fertilization of cumulus-intact oocytes compared with wild-type cells

• however, weakening the zona pellucida improves fertilization rates

impaired binding of sperm to zona pellucida ( J:293874 )

cellular

impaired sperm migration in female genital tract ( J:293874 )

asthenozoospermia ( J:293874 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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