reproductive system
• oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells
• diameter modestly reduced
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• fewer oocytes are recovered following gonadotropin stimulation
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• female mice produce smaller litters
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• female mice produce smaller litters
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embryo
• some embryos from female mice fail to progress normally during pre-implantation and do not form blastocysts
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cellular
• oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells
• diameter modestly reduced
|
• fewer oocytes are recovered following gonadotropin stimulation
|