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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Exosc10em1Dean
endonuclease-mediated mutation 1, Jurrien Dean
MGI:6455039
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Exosc10em1Dean/Exosc10em1Dean involves: C57BL/6J * DBA/2J MGI:6455140


Genotype
MGI:6455140
hm1
Allelic
Composition
Exosc10em1Dean/Exosc10em1Dean
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exosc10em1Dean mutation (0 available); any Exosc10 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells
• diameter modestly reduced
• fewer oocytes are recovered following gonadotropin stimulation
• female mice produce smaller litters
• female mice produce smaller litters

embryo
• some embryos from female mice fail to progress normally during pre-implantation and do not form blastocysts

cellular
• oocytes exhibit defective germinal vesicle breakdown with impaired endomembrane components, including endosomes, lysosomes, endoplasmic reticulum and Golgi compared with wild-type cells
• diameter modestly reduced
• fewer oocytes are recovered following gonadotropin stimulation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory