Phenotypes associated with this allele

• Allele Symbol: Adprs^tm1.2Jlms
• Allele Name: targeted mutation 1.2, Joel Moss
• Allele ID: MGI:6455175
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adprs^tm1.2Jlms/Adprs^tm1.2Jlms	involves: 129 * C57BL/6J * FVB/N * SJL	MGI:6455406

Genotype
MGI:6455406

hm1

• Allelic Composition: Adprs^tm1.2Jlms/Adprs^tm1.2Jlms
• Genetic Background: involves: 129 * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:291285 )

• all mice die within 24 hrs after middle cerebral artery occlusion (MCAO) for an hour or 30 minutes to induce ischemia unlike wild-type mice

nervous system

increased susceptibility to ischemic brain injury ( J:291285 )

• all mice die within 24 hrs after middle cerebral artery occlusion (MCAO) for an hour to induce ischemia unlike wild-type mice mice treated with MCAO for 30 minutes followed by 24-hour reperfusion exhibit larger infarct in the cortex, hippocampus, and striatum with fewer Nissle bodies in cortical neurons, more severe neurological deficits (e.g., loss of walking, more than 80% circling), and increased mortality compared with wild-type mice

• however, treatment with PARP inhibitor veliparib improves symptoms

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:291285 )

• all mice die within 24 hrs after middle cerebral artery occlusion (MCAO) for an hour to induce ischemia unlike wild-type mice mice treated with MCAO for 30 minutes followed by 24-hour reperfusion exhibit larger infarct in the cortex, hippocampus, and striatum with fewer Nissle bodies in cortical neurons, more severe neurological deficits (e.g., loss of walking, more than 80% circling), and increased mortality compared with wild-type mice

• however, treatment with PARP inhibitor veliparib improves symptoms

abnormal susceptibility to injury induced morbidity/mortality ( J:291285 )

• all mice die within 24 hrs after middle cerebral artery occlusion (MCAO) for an hour or 30 minutes to induce ischemia unlike wild-type mice